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There are a number of research projects that we are currently involved in. Through a link with the University of East Anglia and the Institute of Food Research a number of junior doctors have obtained MD theses through our department. Current work involves examination of human stem cells in the colon and in Barretts Oesophagus, a pre-malignant disease of the oesophagus. The lab in the school of Biology is run by Dr Mark Williams. The work has been published and presented:
A novel 3D ex vivo model of native human Barrett’s oesophagusScobioala-laker, Natalia1; Reynolds, Amy1; Parris, Alyson1; Mitchell, Esther M.1; Lewis, Michael P.3; Kennedy, Hugh J.2; Stebbings, William3; Prior, Alison2; Philips, Martin2; Beales, Ian2; Williams, Mark R, Gut May 2009. Belshaw NJ, Pal N, Tapp HS, Dainty JR, Lewis MP, Williams MR, Lund EK, Johnson IT. Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. Carcinogenesis. 2010 Jun;31(6):1158-63.
Outcomes of surgical procedures are routinely collected locally and nationally and can be accessed through AUGIS (National OG cancer audit), the National Bariatric Surgery Registry and PHIN (the Private Healthcare Information Network).
A number of randomised trials based at the Norfolk and Norwich University Hospital have been performed and results published:
1. Intravenous Fluid restriction in GI cancer surgery1
2. Pre-operative very low calorie diet in laparoscopic cholecystectomy2
3. Post-operative statin therapy in oesophageal cancer3
1. doi; 10.1002/bjs.9301
2. doi; 10.1016/j.hpb.2016.01.545
3. doi: 10.1002/bjs5.50239
In addition there have been several collaborations on basic and clinical research with UEA, the Institute of Food research, and NIHR national research projects.